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Johansson P.A., Per Ludvik Brattås P.L., Douse Ch.H., Hsieh PH, Adami A, Pontis J, Grassi D, Garza R, Sozzi E, Cataldo R, Jönsson M.E., Atacho D.A.M., Pircs K, Eren F, Sharma Y, Johansson J, Fiorenzano A, Parmar M, Fex M, Trono D, Eichler E.E.
A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development 
Cell Stem Cell, 7 oktober 2021

Jönsson ME, Garza R, Sharma Y, Petri R, Södersten E, Johansson JG, Johansson PA, Atacho DA, Pircs K, Madsen S, Yudovich D, Ramakrishnan R, Holmberg J, Larsson J, Jern P, Jakobsson J.
Activation of endogenous retroviruses during brain development causes an inflammatory responseOPEN ACCESS
EMBO J. 2021 Mar 1

Klawonn A.M, Fritz M, Castany S, Pignatelli M, Canal C, Similä F, Tejeda H.A,  Levinsson J, Jaarola M, Jakobsson J, Hidalgo J, Heilig M, Bonci A, Engblom D
Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons
Immunity. 2021 Jan 13


Jönsson M E, Garza R, Johansson P A, Jakobsson J  
Transposable Elements: A Common Feature of Neurodevelopmental and Neurodegenerative Disorders OPEN ACCESS 
Trends in Genetics. June 1st, 2020

Brattås PL, Hersbach BA, Madsen S, Petri R, Jakobsson J, Pircs K
Impact of differential and time-dependent autophagy activation on therapeutic efficacy in a model of Huntington disease. OPEN ACCESS
Autophagy. 2020 May 6:1-14

Butler CR, Boychuk JA, Pomerleau F, Alcala R, Huettl P, Ai Y, Jakobsson J, Whiteheart SW, Gerhardt GA, Smith BN, Slevin JT.
Modulation of epileptogenesis: A paradigm for the integration of enzyme-based microelectrode arrays and optogenetics.
Epilepsy Res. 2020 Jan.


Grassi DA, Brattås PL, Jönsson ME, Atacho D, Karlsson O, Nolbrant S, Parmar M, Jakobsson J. 
Profiling of lincRNAs in human pluripotent stem cell derived forebrain neural progenitor cells.  OPEN ACCESS
Heliyon. 2019 Dec 31


Sabelström H, Petri R, Shchors K, Jandial R, Schmidt C, Sacheva R, Masic S, Yuan E, Fenster T, Martinez M, Saxena S, Nicolaides TP, Ilkhanizadeh S, Berger MS, Snyder EY, Weiss WA, Jakobsson J, Persson AI.
Driving Neuronal Differentiation through Reversal of an ERK1/2-miR-124-SOX9 Axis Abrogates Glioblastoma Aggressiveness. OPEN ACCESS
Cell Rep. 2019 Aug 20.

Jönsson ME, Ludvik Brattås P, Gustafsson C, Petri R, Yudovich D, Pircs K, Verschuere S, Madsen S, Hansson J, Larsson J, Månsson R, Meissner A, Jakobsson J.
Activation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors. OPEN ACCESS
Nat Commun. 2019 Jul 18

Petri R, Brattås PL, Sharma Y, Jönsson ME, Pircs K, Bengzon J, Jakobsson J.
LINE-2 transposable elements are a source of functional human microRNAs and target sites. OPEN ACCESS
PLoS Genet. 2019 Mar 13


Kutsche LK, Gysi DM, Fallmann J, Lenk K, Petri R, Swiersy A, Klapper SD, Pircs K, Khattak S, Stadler PF, Jakobsson J, Nowick K, Busskamp V.
Combined Experimental and System-Level Analyses Reveal the Complex Regulatory Network of miR-124 during Human Neurogenesis. OPEN ACCESS
Cell Syst. 2018 Sep 28

Pircs K, Petri R, Jakobsson J.
Crosstalk between MicroRNAs and Autophagy in Adult Neurogenesis: Implications for Neurodegenerative Disorders. OPEN ACCESS
Brain Plast. 2018 Aug 10

Pircs K, Petri R, Madsen S, Brattås PL, Vuono R, Ottosson DR, St-Amour I, Hersbach BA, Matusiak-Brückner M, Hult Lundh S, Petersén Å, Déglon N, Hébert SS, Parmar M, Barker RA, Jakobsson J.
Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation OPEN ACCESS
Cell Reports 24, 1397–1406, August 7, 2018

Grassi DA, Jönsson ME, Brattås PL, Jakobsson J.
TRIM28 and the control of transposable elements in the brain
Brain Res. 2018 Mar 6.

Burmeister, J.J., Pomerleau, F., Quintero, J.E., Huettl, P., Ai, Y., Jakobsson, J., Lundblad, M., Heuer, A., Slevin, J.T., Gerhardt, G.A.
In vivo electrochemical studies of optogenetic control of glutamate signaling measured using enzyme-based ceramic microelectrode arrays.
NeuromethodsVolume 130, 2018, Pages 327-351

Petri R, Jakobsson J
Identifying miRNA Targets Using AGO-RIPseq
Methods Mol Biol. 2018;1720:131-140


Drouin-Ouellet J, Pircs K, Barker RA, Jakobsson J, Parmar M.
Direct Neuronal Reprogramming for Disease Modeling Studies Using Patient-Derived Neurons: What Have We Learned? OPEN ACCESS
Front Neurosci. 2017 Sep 28

Brawek B, Liang Y, Savitska D, Li K, Fomin-Thunemann N, Kovalchuk Y, Zirdum E, Jakobsson J, Garaschuk O
A new approach for ratiometric in vivo calcium imaging of microglia. OPEN ACCESS
Sci Rep. 2017 Jul 20;7(1):6030

Drouin-Ouellet J, Lau S, Brattås PL, Rylander Ottosson D, Pircs K, Grassi DA, Collins LM, Vuono R, Andersson Sjöland A, Westergren-Thorsson G, Graff C, Minthon L, Toresson H, Barker RA, Jakobsson J, Parmar M
REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways. OPEN ACCESS

EMBO Mol Med. 2017 Jun 23.

Petri R, Pircs K, Jönsson ME, Åkerblom M, Brattås PL, Klussendorf T, Jakobsson J
let‐7 regulates radial migration of new‐born neurons through positive regulation of autophagy
EMBO Journal. 23 March 2017.

Alcacer C, Andreoli L, Sebastianutto I, Jakobsson J, Fieblinger T, Cenci MA
Chemogenetic stimulation of striatal projection neurons modulates responses to Parkinson's disease therapy OPEN ACCESS
J Clin Invest. 2017 Jan 23.

Brattås PL, Jönsson ME, Fasching L, Nelander Wahlestedt J, Shahsavani M, Falk R, Falk A, Jern P, Parmar M, Jakobsson J
TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells OPEN ACCESS
Cell Reports. January 3rd, 2017


Malmevik J, Petri R, Knauff P, Brattås PL, Åkerblom M, Jakobsson J
Distinct cognitive effects and underlying transcriptome changes upon inhibition of individual miRNAs in hippocampal neurons.
Sci Rep. 2016 Jan 27;6:19879


Fritz M, Klawonn AM, Nilsson A, Singh AK, Zajdel J, Björk Wilhelms D, Lazarus M, Löfberg A, Jaarola M, Örtegren Kugelberg U, Billiar TR, Hackam DJ, Sodhi CP, Breyer MD, Jakobsson J, Schwaninger M, Schütz G, Rodriguez Parkitna J, Saper CB, Blomqvist A, Engblom D
Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice OPEN ACCESS
Journal of Clinical Investigation. 2015 Dec 21. pii: 83844.

Jönsson ME, Nelander Wahlestedt J, Åkerblom M, Kirkeby A, Malmevik J, Brattaas PL, Jakobsson J, Parmar M
Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor  OPEN ACCESS
Development. 2015 Sep 15;142(18):3166-77.

Malmevik J, Petri R, Klussendorf T, Knauff P, Åkerblom M, Johansson J, Soneji S, Jakobsson J
Identification of the miRNA targetome in hippocampal neurons using RIP-seq OPEN ACCESS
Scientific Reports 5, Article number: 12609 (2015). Published online: 28 July 2015

Grealish S, Heuer A, Cardoso T, Kirkeby A, Jönsson M, Johansson J, Björklund A, Jakobsson J, Parmar M
Monosynaptic Tracing using Modified Rabies Virus Reveals Early and Extensive Circuit Integration of Human Embryonic Stem Cell-Derived Neurons OPEN ACCESS
Stem Cell Reports. 2015 May 20

Fasching L, Kapopoulou A, Sachdeva R, Petri R, Jönsson M E, Männe C, Turelli P, Jern P, Cammas F, Trono D, Jakobsson J
TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells OPEN ACCESS
Cell Reports, 2015 Jan 6;10(1):20-8


Lau S, Ryllander Ottosson D, Jakobsson J, Parmar M
Direct Neural Conversion from Human Fibroblasts Using Self-Regulating and Nonintegrating Viral Vectors OPEN ACCESS
Cell Reports, Volume 9, Issue 5, p1673–1680, 11 December 2014

Åkerblom M, Petri R, Sachdeva R, Klussendorf T, Mattsson B, Gentner B, Jakobsson J
microRNA-125 distinguishes developmentally generated and adult-born olfactory bulb interneurons OPEN ACCESS
Development. March 5, 2014


Malmevik J, Åkerblom M, Jakobsson J
microRNA and Neurodegenarative diseases
book chapter in: microRNAs in Toxicology and Medicine, editor Saura C. Sahu, October 2013

Petri R, Malmevik J, Fasching L, Åkerblom M, Jakobsson J
miRNAs in brain development
Experimental Cell Research. 2013 Oct 4

Åkerblom M, Jakobsson J
MicroRNAs as Neuronal Fate Determinants
Neuroscientist. 2013 Jul 22.

Decressac M,  Mattsson B, Weikop P, Lundblad M, Jakobsson J, Björklund A
TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity
PNAS April 22, 2013

Åkerblom M, Sachdeva R, Quintino L, Elgstrand Wettergren E, Chapman K Z, Manfre G, Lindvall O, Lundberg C, Jakobsson J
Visualization and genetic modification of resident brain microglia using lentiviral vectors regulated by microRNA-9
Nature Communications 4, Article number: 1770. 23 April 2013.

Torper O, Pfisterer U, Wolf DA, Pereira M, Lau S, Jakobsson J, Björklund A, Grealish S, Parmar M
Generation of induced neurons via direct conversion in vivo
PNAS, March 25, 2013


Rowe H M, Kapopoulou A, Corsinotti A, Fasching L, Macfarlan TS, Tarabay Y, Viville S, Jakobsson J, Pfaff S L, Trono D
TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells
Genome Research, December 10, 2012.

Åkerblom M, Sachdeva R, Barde I, Verp S, Gentner B, Trono D, Jakobsson J
MicroRNA-124 Is a Subventricular Zone Neuronal Fate Determinant
Journal of Neuroscience. 27 June 2012, Volume 32, Issue 26, pp 8879 to 8889

Åkerblom M, Sachdeva R, Jakobsson J
Functional studies of microRNAs in neural stem cells: problems and perspectives
Frontiers in neurogenesis. 07 February 2012.


Quenneville S, Verde G, Corsinotti A, Kapopoulou A, Jakobsson J, Offner S, Baglivo I, Pedone PV, Grimaldi G, Riccio A, Trono D.
In Embryonic Stem Cells, ZFP57/KAP1 Recognize a Methylated Hexanucleotide to Affect Chromatin and DNA Methylation of Imprinting Control Regions.
Mol Cell. 2011 Nov 4;44(3):361-72.

Grealish S, Jakobsson J, Parmar M.
Lineage reprogramming : A shortcut to generating functional neurons from fibroblasts. 
Cell Cycle. 2011 Oct 15;10(20):3421-2

Parmar M, Jakobsson J
Turning skin into dopamine neurons
Cell Research, online publication 9 August 2011

Pfisterer U, Kirkeby A, Torper O, Wood J, Nelander J, Dufour A, Björklund A, Lindvall O, Jakobsson J, Parmar M.
Direct conversion of human fibroblasts to dopaminergic neurons.
Proc Natl Acad Sci U S A. 2011 Jun 6.

Kirkeby A, Parmar M, Jakobsson J
Using endogenous microRNA expression patterns to visualize neural differentiation of human pluripotent stem cells
Methods in Molecular Biology, 2011 Jul 30.


Sachdeva R, Jönsson M, Nelander J, Kirkeby A, Gentner B, Naldini L, Björklund A, Parmar M and Jakobsson J.
Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors.  
PNAS  2010 Jun 22;107(25):11602-7.

Rowe HM, Jakobsson J, Mesnard D, Rougemont J, Reynard S, Aktas T, Maillard PV, Layard-Liesching H, Verp S, Marquis J, Spitz F, Constam DB, Trono D.
KAP1 controls endogenous retroviruses in embryonic stem cells. 
Nature 2010 463:237-40


Tolstrup Nielsen T, Jakobsson J, Rosenqvist N and Lundberg C.
Incorporating double copies of a chromatin insulator into lentiviral vectors results in less lentiviral integrants.  
BMC Biotechnology, 2009 9:13


Jakobsson J,  Cordero MI, Bisaz R, Busskamp V, Bensadoun JC, Cammas F, Losson R, Mansuy IM, Sandi C and Trono D.
KAP1-mediated epigenetic repression in the forebrain modulates behavioral vulnerability to stress. 
Neuron, 2008 60:818-31

Lundberg C, Björklund T, Carlsson T, Jakobsson J, Hantraye P, Déglon N and Kirik D.
Applications of lentiviral vectors for biology and gene therapy of neurological disorders.  
Current Gene Therapy, 2008 8:461-73


Wiznerowicz M, Jakobsson J,  Szulc J, Liao S, Quazzola A, Beermann F, Aebischer P and Trono D.
The Kruppel-associated box repressor domain can trigger de novo promoter methylation during mouse early embryogenesis.  
Journal of Biological Chemistry, 2007 282:34535-4


Jakobsson J, Rosenqvist N, Marild K, V Agoston D and Lundberg C.
Evidence for disease-regulated transgene expression in the brain with the use of lentiviral vectors.  
Journal of Neuroscience Research 2006 84 :58-67  

Jakobsson J and Lundberg C.
Lentiviral vectors for use in the central nervous system.  
Molecular Therapy  2006 13:484-93

Jakobsson J, Tolstrup Nielsen T, Staflin K, Georgievska B and Lundberg C.
Efficient transduction of neurons using Ross River glycoprotein pseudotyped lentiviral vectors.  
Gene Therapy  2006 13:966-73


Rosenqvist N, Jakobsson J and Lundberg C. 
Inhibition of chromatin condensation prevents transgene silencing in a neural progenitor cell line transplanted to the rat brain.  
Cell Transplantation   2005 14:129-38


Georgievska B, Jakobsson J, Persson E, Ericson C, Kirik D and Lundberg C.
Regulated delivery of GDNF in the rat striatum using a tetracycline-dependent lentiviral vector.  
Human Gene Therapy  2004 15:934-44     

Jakobsson J, Rosenqvist N, Thompson L, Barraud P and Lundberg C.
Dynamics of transgene expression in a neural stem cell line transduced with lentiviral vectors incorporating the cHS4-insulator.  
Experimental Cell Research 2004  298 : 611-23   

Jakobsson J,  Georgievska B, Ericson C and Lundberg C (2004)
Lesion-dependent regulation of transgene expression using a human glial fibrillary acidic protein-lentiviral vector.  
European Journal of Neuroscience  2004 19:761-5


Jakobsson J, Ericson C, Jansson M, Bjork E and Lundberg C. 
Targeted transgene expression in the rat brain using lentiviral vectors.  
Journal of Neuroscience Research  2003  73:876-85

Jakobsson J, Ericson C, Rosenqvist N and Lundberg C.
Lentiviral vectors.
International Reviews in Neurobiology  2003 55:111-22